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NEUROPEPTIDES

PE-22-28

$89.99 $106.99
Limited Batch Pricing
Ends Monday, Jun 1 at 12:59 AM EDT
Free worldwide shipping HPLC ≥97% purity COA included
For research use only. Not intended for human consumption.

About this compound

TREK-1 channel blocker with rapid antidepressant and nootropic effects. Upregulates BDNF and stimulates hippocampal neurogenesis for mood and cognition.

Product Details

PE-22-28 is a synthetic peptide with a molecular weight of 808.93 g/mol and molecular formula C40H56N10O8. Supplied as a lyophilised solid, each batch is verified to ≥98% purity via HPLC analysis and accompanied by a Certificate of Analysis (COA).

PE-22-28 is soluble in dmso and dilute aqueous buffers. For optimal stability, store the unopened vial at -20 °C, desiccated. Stable for up to 14 days at 2–8 °C in aqueous solution under sterile conditions.

PE-22-28 (Mini-Spadin) is a synthetic peptide derived from sortilin that acts as a TREK-1 potassium channel blocker. TREK-1 channels are involved in mood regulation, and their inhibition has been shown to produce rapid antidepressant and anxiolytic effects in animal models, potentially faster than traditional SSRIs. PE-22-28 also upregulates BDNF (brain-derived neurotrophic factor) and stimulates neurogenesis in the hippocampus.

Why LarnaLabs

Every compound we supply is synthesized in ISO-certified GMP facilities using automated solid-phase peptide synthesis, ensuring batch-to-batch consistency and accurate sequencing.

Each batch undergoes independent third-party testing — HPLC for purity verification (≥97%), mass spectrometry for identity confirmation, and endotoxin screening (<1 EU/μg). A full Certificate of Analysis ships with every order.

We offer free worldwide shipping with temperature-controlled packaging, anonymous checkout for your privacy, and responsive support from a team that understands research-grade compounds.

Identification
Molecular Weight (g/mol)808.93
Molecular FormulaC40H56N10O8
Peptide SequenceAc-Tyr-Tyr-Met-Asp-Trp-Phe-NH2
Product NamePE-22-28
Catalogue NumberLL-PE2228-5
CAS NumberN/A (research compound)
Physical and Chemical Properties
Active IngredientPE-22-28
AppearanceWhite lyophilised powder
FormLyophilised Solid
Purity (HPLC)≥98%
SolubilitySoluble in DMSO and dilute aqueous buffers
Analytical and Quality Control
Mass SpectrumConforms to specification (808.93 g/mol)
Amino Acid CompositionConsistent with the theoretical peptide sequence
Endotoxin< 1 EU/μg by LAL method
Research Use and Safety
CautionHandle using appropriate PPE and in compliance with relevant laboratory safety standards.
Intended UseFor laboratory research use only. Not for human or veterinary use.
Hazard ClassificationNot classified as hazardous under GHS for research quantities
Storage, Handling and Stability
Storage Temperature, Opened-20 °C, minimise freeze-thaw cycles
Storage Temperature, Unopened-20 °C, desiccated
Shelf Life2 years unopened under recommended conditions
Reconstitution StabilityStable for up to 14 days at 2–8 °C in aqueous solution under sterile conditions

Shipping

All orders include free worldwide shipping with tracking. Orders are dispatched within 1-2 business days and typically arrive within 5-10 business days depending on destination.

Shipments are temperature-controlled and packaged to maintain compound integrity during transit. Shipping protection is included at no extra cost.

Returns & Refunds

If your order arrives damaged or does not meet stated purity specifications, contact us within 14 days for a full replacement or refund. A COA discrepancy or verified shipping damage is required for processing.

All products are shipped in compliance with applicable regulations for research-use materials. Customs duties or import fees, if applicable, are the responsibility of the buyer.